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免疫联合靶向治疗已成为晚期肾癌一线标准治疗,并且在围术期阶段取得了突破性进展。此外,以免疫治疗为核心的联合治疗策略正在多种肾癌治疗场景中进行积极探索,但目前缺乏指南和共识指导临床实践。中华医学会泌尿外科学分会肾癌协作组,基于肾癌免疫治疗最新临床研究数据,组织专家组成员深入研究讨论,共同制定了本共识。详尽阐述了局部进展期肾癌以及转移性或不可切除肾癌的免疫治疗推荐,同时对外科治疗与免疫治疗之间的关系以及靶免联合治疗的不良反应管理问题进行了讨论,以期为临床提供指引。
Abstract:Immunotherapy combined with targeted therapy has become the first-line standard treatment for advanced renal cell carcinoma(RCC) and has made groundbreaking progress in the perioperative setting. Furthermore, immunotherapy-centered combination strategies are actively being explored in various clinical scenarios for RCC.However, there is currently a lack of guidelines and consensus to direct clinical practice. Based on the latest clinical research data on immunotherapy for RCC, the Chinese Kidney Cancer Consortium Chinese Urological Association organized an in-depth discussion among expert panel members to develop this consensus. This document provides detailed recommendations for immunotherapy in locally advanced RCC and metastatic or unresectable RCC. It also discuss the relationship between surgical treatment and immunotherapy, as well as the management of adverse events associated with immunotherapy combined with targeted therapy, aiming to offer guidance for clinical practice.
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基本信息:
DOI:10.19558/j.cnki.10-1020/r.2025.02.001
中图分类号:R737.11
引用信息:
[1]中华医学会泌尿外科学分会肾癌研究协作组,张旭,何志嵩,等.肾癌免疫治疗中国专家共识[J].微创泌尿外科杂志,2025,14(02):73-83.DOI:10.19558/j.cnki.10-1020/r.2025.02.001.